| Item type |
Multiple(1) |
| 公開日 |
2025-03-28 |
| タイトル |
|
|
タイトル |
Clinical significance of NF2 alteration in grade I meningiomas revisited; prognostic impact integrated with extent of resection, tumour location, and Ki-67 index |
|
言語 |
eng |
| 作成者 |
Teranishi
Okano
Miyawaki
Ohara
Ishigami
Hongo
Dofuku
Takami
Mitsui
Ikemura
Komura
Katoh
Ushiku
Ishikawa
shin
Nakatomi
Saito
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
言語 |
eng |
|
主題Scheme |
Other |
|
主題 |
Meningioma genomics |
| 主題 |
|
|
言語 |
eng |
|
主題Scheme |
Other |
|
主題 |
Precision medicine |
| 主題 |
|
|
言語 |
eng |
|
主題Scheme |
Other |
|
主題 |
Tumor location |
| 主題 |
|
|
言語 |
eng |
|
主題Scheme |
Other |
|
主題 |
Tumor prognosis |
| 主題 |
|
|
言語 |
eng |
|
主題Scheme |
Other |
|
主題 |
WHO grade |
| 主題 |
|
|
言語 |
eng |
|
主題Scheme |
SciVal |
|
主題 |
Pathology and Forensic Medicine |
| 主題 |
|
|
言語 |
jpn |
|
主題Scheme |
SciVal |
|
主題 |
病理学および法医学 |
| 主題 |
|
|
言語 |
eng |
|
主題Scheme |
SciVal |
|
主題 |
Clinical Neurology |
| 主題 |
|
|
言語 |
jpn |
|
主題Scheme |
SciVal |
|
主題 |
臨床神経学 |
| 主題 |
|
|
言語 |
eng |
|
主題Scheme |
SciVal |
|
主題 |
Cellular and Molecular Neuroscience |
| 主題 |
|
|
言語 |
jpn |
|
主題Scheme |
SciVal |
|
主題 |
細胞および分子神経科学 |
| 内容記述 |
|
|
内容記述 |
<p>NF2 alteration is the most commonly–found genetic abnormality in meningiomas and is known to initiate events for aggressive-type meningiomas. Whereas the prognosis of meningiomas differs depending on their epigenomic/transcriptomic profile, the effect of NF2 alteration on the prognosis of benign meningiomas is not fully elucidated. This study aimed to probe the importance of NF2 alteration in prognosis of WHO grade I meningiomas. A long-term retrospective follow-up (5.3 ± 4.5 years) study involving 281 consecutive WHO grade I meningioma patients was performed. We assessed tumour recurrence in correlation with extent of resection (EOR), histopathological findings, tumour location, and NF2 alteration. “NF2 meningioma” was defined as meningiomas with presence of NF2 mutation and/or 22q loss. Overall, NF2 meningioma per se was not a predictor of prognosis in the whole cohort; however, it was a predictor of recurrence in supratentorial meningiomas, together with EOR and Ki-67. In a striking contrast, NF2 meningioma showed a better prognosis than non-NF2 meningioma in infratentorial lesion. Supratentorial NF2 meningiomas had higher Ki-67 and forkhead box protein M1 expression than those of others, possibly explaining the worse prognosis in this subtype. The combination of NF2 alteration, high Ki-67 and supratentorial location defines subgroup with the worst prognosis among WHO grade I meningiomas. Clinical connotation of NF2 alteration in terms of prognosis of WHO grade I meningioma differs in an opposite way between supratentorial and infratentorial tumors. Integrated anatomical, histopathological, and genomic classifications will provide the best follow-up schedule and proactive measures.</p> |
|
言語 |
eng |
| 日付 |
|
|
日付 |
2022-12 |
|
日付タイプ |
Issued |
| Language |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| バージョン情報 |
|
|
バージョン情報 |
76 |
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
PubMed |
|
|
関連識別子 |
35570314 |
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
QABO |
|
|
関連識別子 |
85130043141 |
| 収録物名 |
|
|
収録物名 |
Acta neuropathologica communications |
| 巻 |
|
|
巻 |
10 |
| 号 |
|
|
号 |
1 |
