Hepatocellular carcinoma development in diabetic patients: class FormattedString {
    value: a nationwide survey in Japan
}

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Hepatocellular carcinoma development in diabetic patients: class FormattedString {
value: a nationwide survey in Japan
}

https://localhost/en/publications/0643c0ca-1193-48cf-bcee-4c16898866fc

Item type

Multiple(1)

公開日

2025-03-26

タイトル

Hepatocellular carcinoma development in diabetic patients: class FormattedString {
value: a nationwide survey in Japan
}

言語

eng

作成者

Tateishi
Matsumura
Okanoue
Shima
Uchino
Fujiwara
Senokuchi
Kon
Sasako
Taniai
Kawaguchi
Inoue
Watada
Kubota
Shimano
Kaneko
Hashimoto
Watanabe
Shiota
Ueki
Kashiwabara
Matsuyama
Tanaka
Kasuga
Araki
Koike
Karino
Hige
Sekiguchi
Ogawa
Miyoshi
Cho
Baba
Inoue
Aso
Okada
Takikawa
Endo
Ishigaki
Togashi
Unno
Morikawa
Katagiri
Sawada
Ohira
Takahashi
Shimabukuro
Kudo
Tanaka
kikuchi

アクセス権

open access

アクセス権URI

http://purl.org/coar/access_right/c_abf2

主題

言語

eng

主題Scheme

Other

主題

FIB-4 index

主題

言語

eng

主題Scheme

Other

主題

Hepatocellular carcinoma

主題

言語

eng

主題Scheme

Other

主題

Type 2 diabetes mellitus

主題

言語

eng

主題Scheme

SciVal

主題

Gastroenterology

主題

言語

jpn

主題Scheme

SciVal

主題

消化器病学

主題

言語

eng

主題Scheme

SDG

主題

SDG 3 - Good Health and Well-being

主題

言語

jpn

主題Scheme

SDG

主題

SDG 3 - すべての人に健康と福祉を

内容記述

<p>Background: Although type 2 diabetes mellitus (T2DM) is a known risk factor for hepatocellular carcinoma (HCC) development, the annual incidence in diabetes patients is far below the threshold of efficient surveillance. This study aimed to elucidate the risk factors for HCC in diabetic patients and to determine the best criteria to identify surveillance candidates. Methods: The study included 239 patients with T2DM who were diagnosed with non-viral HCC between 2010 and 2015, with ≥ 5 years of follow-up at diabetes clinics of 81 teaching hospitals in Japan before HCC diagnosis, and 3277 non-HCC T2DM patients from a prospective cohort study, as controls. Clinical data at the time of and 5 years before HCC diagnosis were collected. Results: The mean patient age at HCC diagnosis was approximately 73 years, and 80% of the patients were male. The proportion of patients with insulin use increased, whereas the body mass index (BMI), proportion of patients with fatty liver, fasting glucose levels, and hemoglobin A1c (HbA1c) levels decreased significantly in 5 years. In the cohort study, 18 patients developed HCC during the mean follow-up period of 4.7 years with an annual incidence of 0.11%. Multivariate logistic regression analyses showed that the FIB-4 index was an outstanding predictor of HCC development along with male sex, presence of hypertension, lower HbA1c and albumin levels, and higher BMI and gamma-glutamyl transpeptidase levels. Receiver-operating characteristic analyses showed that a FIB-4 cut-off value of 3.61 could help identify high-risk patients, with a corresponding annual HCC incidence rate of 1.1%. Conclusion: A simple calculation of the FIB-4 index in diabetes clinics can be the first step toward surveillance of HCC with a non-viral etiology.</p>

言語

eng

日付

2021-3

日付タイプ

Issued

Language

言語

eng

資源タイプ

資源タイプ識別子

http://purl.org/coar/resource_type/c_6501

資源タイプ

journal article

Versions

Ver.1

2025-04-01 03:25:38.591216

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アイテム

Hepatocellular carcinoma development in diabetic patients: class FormattedString { value: a nationwide survey in Japan}

× Tateishi

× Matsumura

× Okanoue

× Shima

× Uchino

× Fujiwara

× Senokuchi

× Kon

× Sasako

× Taniai

× Kawaguchi

× Inoue

× Watada

× Kubota

× Shimano

× Kaneko

× Hashimoto

× Watanabe

× Shiota

× Ueki

× Kashiwabara

× Matsuyama

× Tanaka

× Kasuga

× Araki

× Koike

× Karino

× Hige

× Sekiguchi

× Ogawa

× Miyoshi

× Cho

× Baba

× Inoue

× Aso

× Okada

× Takikawa

× Endo

× Ishigaki

× Togashi

× Unno

× Morikawa

× Katagiri

× Sawada

× Ohira

× Takahashi

× Shimabukuro

× Kudo

× Tanaka

× kikuchi

Versions

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エクスポート

Hepatocellular carcinoma development in diabetic patients: class FormattedString {
value: a nationwide survey in Japan
}