{"created":"2025-04-14T23:26:12.062603+00:00","id":2024829,"links":{},"metadata":{"_buckets":{"deposit":"e4a0ed37-d167-4cad-ba55-0e8151fa1268"},"_deposit":{"id":"2024829","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2024829"},"status":"published"},"_oai":{"id":"oai:teikyo-u.repo.nii.ac.jp:02024829","sets":["1726879085919:1741828256493"]},"author_link":[],"item_1551264308487":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: Analysis with a dose-dependent clearance model","subitem_title_language":"eng"}]},"item_1551264340087":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"familyNames":[{"familyName":"Odani"}],"givenNames":[{"givenName":"Atsuko"}]},{"familyNames":[{"familyName":"Hashimoto"}],"givenNames":[{"givenName":"Yukiya"}]},{"familyNames":[{"familyName":"Takayanagi"}],"givenNames":[{"givenName":"Kazunobu"}]},{"familyNames":[{"familyName":"Otsuki"}],"givenNames":[{"givenName":"Yuko"}]},{"familyNames":[{"familyName":"Koue"}],"givenNames":[{"givenName":"Toshiko"}]},{"familyNames":[{"familyName":"Takano"}],"givenNames":[{"givenName":"Mikihisa"}]},{"familyNames":[{"familyName":"yasuhara","familyNameLang":"eng"},{"familyName":"安原","familyNameLang":"jpn"}],"givenNames":[{"givenName":"masato","givenNameLang":"eng"},{"givenName":"眞人","givenNameLang":"jpn"}]},{"familyNames":[{"familyName":"Hattori"}],"givenNames":[{"givenName":"Haruo"}]},{"familyNames":[{"familyName":"Furusho"}],"givenNames":[{"givenName":"Kenshi"}]},{"familyNames":[{"familyName":"Inui"}],"givenNames":[{"givenName":"Ken Ichi"}]}]},"item_1551264447183":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1551264822581":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Michaelis-Menten elimination","subitem_subject_language":"eng","subitem_subject_scheme":"Other"},{"subitem_subject":"nonlinear mixed effects model (NONMEM)","subitem_subject_language":"eng","subitem_subject_scheme":"Other"},{"subitem_subject":"phenytoin","subitem_subject_language":"eng","subitem_subject_scheme":"Other"},{"subitem_subject":"population pharmacokinetics","subitem_subject_language":"eng","subitem_subject_scheme":"Other"},{"subitem_subject":"zonisamide","subitem_subject_language":"eng","subitem_subject_scheme":"Other"},{"subitem_subject":"Pharmacology","subitem_subject_language":"eng","subitem_subject_scheme":"SciVal"},{"subitem_subject":"薬理学","subitem_subject_language":"jpn","subitem_subject_scheme":"SciVal"},{"subitem_subject":"Pharmaceutical Science","subitem_subject_language":"eng","subitem_subject_scheme":"SciVal"},{"subitem_subject":"薬科学","subitem_subject_language":"jpn","subitem_subject_scheme":"SciVal"}]},"item_1551264846237":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"<p>The population pharmacokinetic parameters of phenytoin were estimated using routine therapeutic drug monitoring data from 116 epileptic patients. The 531 serum concentration values at steady-state after repetitive oral administration were analyzed using a nonlinear mixed effects model (NONMEM) program designed for estimation of population pharmacokinetic parameters. A one-compartment model with dose-dependent clearance was used for the pharmacokinetic analysis of phenytoin. The volume of distribution (V) was estimated to be 1.23I/kg in a typical 42-kg patient, assuming that the bioavailability of orally administered phenytoin is 100%. The maximal elimination rate (V(max)) and the Michaelis-Menten constant (K(m)) were 9.80 mg/d/kg and 9.19 μg/ml, respectively. The parameter of power function of weight to adjust V and V(max) was estimated to be 0.463. In addition, K(m) for phenytoin appeared to be 16% increased in patients receiving zonisamide concurrently. The population pharmacokinetic parameters of phenytoin will he useful for designing dosage regimens in epileptic patients.</p>","subitem_description_language":"eng"}]},"item_1551264974654":{"attribute_name":"Date","attribute_value_mlt":[{"subitem_date_issued_datetime":"1996-3","subitem_date_issued_type":"Issued"}]},"item_1551265002099":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1551265032053":{"attribute_name":"item_1551265032053","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1551265227803":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"8924916","subitem_relation_type_select":"PubMed"}},{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"13244300645","subitem_relation_type_select":"QABO"}},{"subitem_relation_type":"isPartOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"0918-6158","subitem_relation_type_select":"ISSN"}}]},"item_1551265438256":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_source_title":"Biological and Pharmaceutical Bulletin"}]},"item_1551265463411":{"attribute_name":"巻","attribute_value_mlt":[{"subitem_volume":"19"}]},"item_1551265520160":{"attribute_name":"号","attribute_value_mlt":[{"subitem_issue":"3"}]},"item_1551265553273":{"attribute_name":"ページ数","attribute_value_mlt":[{"subitem_number_of_pages":"5"}]},"item_1551265569218":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"444"},{"subitem_start_page":"448"}]},"item_title":"Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: Analysis with a dose-dependent clearance model","item_type_id":"12","owner":"1","path":["1741828256493"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-03-30"},"publish_date":"2025-03-30","publish_status":"0","recid":"2024829","relation_version_is_last":true,"system_identifier_doi":{"attribute_name":"Persistent Identifier(DOI)","attribute_value_mlt":[{"subitem_systemidt_identifier":"https://pure.teikyo.jp/en/publications/4706840f-319e-4fc7-957e-106e8b39e964","subitem_systemidt_identifier_type":"URI"},{"subitem_systemidt_identifier":"https://doi.org/10.1248/bpb.19.444","subitem_systemidt_identifier_type":"DOI"}]},"title":["Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: Analysis with a dose-dependent clearance model"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2025-04-17T10:02:53.093175+00:00"}